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2018
Nazaré, Ana Carolina; Polaquini, Carlos Roberto; Cavalca, Lúcia Bonci; Anselmo, Daiane Bertholin; Saiki, Marilia Freitas Calmon; Monteiro, Diego Alves; Zielinska, Aleksandra; Rahal, Paula; Gomes, Eleni; Scheffers, Dirk Jan; Ferreira, Henrique; Regasini, Luis Octavio
Design of Antibacterial Agents: Alkyl Dihydroxybenzoates against Xanthomonas citri subsp. citri Journal Article
Em: International Journal of Molecular Sciences 2018, Vol. 19, Page 3050, vol. 19, iss. 10, pp. 3050, 2018, ISSN: 1422-0067.
Resumo | Links | BibTeX | Tags: Antimicrobial, Citrus canker, membrane disruption, phenolic acids, plant disease
@article{nokey,
title = {Design of Antibacterial Agents: Alkyl Dihydroxybenzoates against Xanthomonas citri subsp. citri},
author = {Ana Carolina Nazaré and Carlos Roberto Polaquini and Lúcia Bonci Cavalca and Daiane Bertholin Anselmo and Marilia Freitas Calmon Saiki and Diego Alves Monteiro and Aleksandra Zielinska and Paula Rahal and Eleni Gomes and Dirk Jan Scheffers and Henrique Ferreira and Luis Octavio Regasini},
url = {https://www.mdpi.com/1422-0067/19/10/3050/htm https://www.mdpi.com/1422-0067/19/10/3050},
doi = {10.3390/IJMS19103050},
issn = {1422-0067},
year = {2018},
date = {2018-01-01},
journal = {International Journal of Molecular Sciences 2018, Vol. 19, Page 3050},
volume = {19},
issue = {10},
pages = {3050},
publisher = {Multidisciplinary Digital Publishing Institute},
abstract = {Xanthomonas citri subsp. citri (Xcc) causes citrus canker, affecting sweet orange-producing areas around the world. The current chemical treatment available for this disease is based on cupric compounds. For this reason, the objective of this study was to design antibacterial agents. In order to do this, we analyzed the anti-Xcc activity of 36 alkyl dihydroxybenzoates and we found 14 active compounds. Among them, three esters with the lowest minimum inhibitory concentration values were selected; compounds 4 (52 μM), 16 (80 μM) and 28 (88 μM). Our study demonstrated that alkyl dihydroxybenzoates cause a delay in the exponential phase. The permeability capacity of alkyl dihydroxybenzoates in a quarter of MIC was compared to nisin (positive control). Compound 28 was the most effective (93.8), compared to compound 16 (41.3) and compound 4 (13.9) by percentage values. Finally, all three compounds showed inhibition of FtsZ GTPase activity, and promoted changes in protofilaments, leading to depolymerization, which prevents bacterial cell division. In conclusion, heptyl dihydroxybenzoates (compounds 4, 16 and 28) are promising anti-Xcc agents which may serve as an alternative for the control of citrus canker.},
keywords = {Antimicrobial, Citrus canker, membrane disruption, phenolic acids, plant disease},
pubstate = {published},
tppubtype = {article}
}
Xanthomonas citri subsp. citri (Xcc) causes citrus canker, affecting sweet orange-producing areas around the world. The current chemical treatment available for this disease is based on cupric compounds. For this reason, the objective of this study was to design antibacterial agents. In order to do this, we analyzed the anti-Xcc activity of 36 alkyl dihydroxybenzoates and we found 14 active compounds. Among them, three esters with the lowest minimum inhibitory concentration values were selected; compounds 4 (52 μM), 16 (80 μM) and 28 (88 μM). Our study demonstrated that alkyl dihydroxybenzoates cause a delay in the exponential phase. The permeability capacity of alkyl dihydroxybenzoates in a quarter of MIC was compared to nisin (positive control). Compound 28 was the most effective (93.8), compared to compound 16 (41.3) and compound 4 (13.9) by percentage values. Finally, all three compounds showed inhibition of FtsZ GTPase activity, and promoted changes in protofilaments, leading to depolymerization, which prevents bacterial cell division. In conclusion, heptyl dihydroxybenzoates (compounds 4, 16 and 28) are promising anti-Xcc agents which may serve as an alternative for the control of citrus canker.
Nazaré, Ana Carolina; Polaquini, Carlos Roberto; Cavalca, Lúcia Bonci; Anselmo, Daiane Bertholin; Saiki, Marilia Freitas Calmon; Monteiro, Diego Alves; Zielinska, Aleksandra; Rahal, Paula; Gomes, Eleni; Scheffers, Dirk Jan; Ferreira, Henrique; Regasini, Luis Octavio
Design of Antibacterial Agents: Alkyl Dihydroxybenzoates against Xanthomonas citri subsp. citri Journal Article
Em: International Journal of Molecular Sciences 2018, Vol. 19, Page 3050, vol. 19, iss. 10, pp. 3050, 2018, ISSN: 1422-0067.
Resumo | Links | BibTeX | Tags: Antimicrobial, Citrus canker, membrane disruption, phenolic acids, plant disease
@article{nokey,
title = {Design of Antibacterial Agents: Alkyl Dihydroxybenzoates against Xanthomonas citri subsp. citri},
author = {Ana Carolina Nazaré and Carlos Roberto Polaquini and Lúcia Bonci Cavalca and Daiane Bertholin Anselmo and Marilia Freitas Calmon Saiki and Diego Alves Monteiro and Aleksandra Zielinska and Paula Rahal and Eleni Gomes and Dirk Jan Scheffers and Henrique Ferreira and Luis Octavio Regasini},
url = {https://www.mdpi.com/1422-0067/19/10/3050/htm https://www.mdpi.com/1422-0067/19/10/3050},
doi = {10.3390/IJMS19103050},
issn = {1422-0067},
year = {2018},
date = {2018-01-01},
journal = {International Journal of Molecular Sciences 2018, Vol. 19, Page 3050},
volume = {19},
issue = {10},
pages = {3050},
publisher = {Multidisciplinary Digital Publishing Institute},
abstract = {Xanthomonas citri subsp. citri (Xcc) causes citrus canker, affecting sweet orange-producing areas around the world. The current chemical treatment available for this disease is based on cupric compounds. For this reason, the objective of this study was to design antibacterial agents. In order to do this, we analyzed the anti-Xcc activity of 36 alkyl dihydroxybenzoates and we found 14 active compounds. Among them, three esters with the lowest minimum inhibitory concentration values were selected; compounds 4 (52 μM), 16 (80 μM) and 28 (88 μM). Our study demonstrated that alkyl dihydroxybenzoates cause a delay in the exponential phase. The permeability capacity of alkyl dihydroxybenzoates in a quarter of MIC was compared to nisin (positive control). Compound 28 was the most effective (93.8), compared to compound 16 (41.3) and compound 4 (13.9) by percentage values. Finally, all three compounds showed inhibition of FtsZ GTPase activity, and promoted changes in protofilaments, leading to depolymerization, which prevents bacterial cell division. In conclusion, heptyl dihydroxybenzoates (compounds 4, 16 and 28) are promising anti-Xcc agents which may serve as an alternative for the control of citrus canker.},
keywords = {Antimicrobial, Citrus canker, membrane disruption, phenolic acids, plant disease},
pubstate = {published},
tppubtype = {article}
}
Xanthomonas citri subsp. citri (Xcc) causes citrus canker, affecting sweet orange-producing areas around the world. The current chemical treatment available for this disease is based on cupric compounds. For this reason, the objective of this study was to design antibacterial agents. In order to do this, we analyzed the anti-Xcc activity of 36 alkyl dihydroxybenzoates and we found 14 active compounds. Among them, three esters with the lowest minimum inhibitory concentration values were selected; compounds 4 (52 μM), 16 (80 μM) and 28 (88 μM). Our study demonstrated that alkyl dihydroxybenzoates cause a delay in the exponential phase. The permeability capacity of alkyl dihydroxybenzoates in a quarter of MIC was compared to nisin (positive control). Compound 28 was the most effective (93.8), compared to compound 16 (41.3) and compound 4 (13.9) by percentage values. Finally, all three compounds showed inhibition of FtsZ GTPase activity, and promoted changes in protofilaments, leading to depolymerization, which prevents bacterial cell division. In conclusion, heptyl dihydroxybenzoates (compounds 4, 16 and 28) are promising anti-Xcc agents which may serve as an alternative for the control of citrus canker.