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2020
Morão, Luana G.; Lorenzoni, André S. G.; Chakraborty, Parichita; Ayusso, Gabriela M.; Cavalca, Lucia B.; Santos, Mariana B.; Marques, Beatriz C.; Dilarri, Guilherme; Zamuner, Caio; Regasini, Luis O.; Ferreira, Henrique; Scheffers, Dirk Jan
Investigating the Modes of Action of the Antimicrobial Chalcones BC1 and T9A Journal Article
Em: Molecules 2020, Vol. 25, Page 4596, vol. 25, iss. 20, pp. 4596, 2020, ISSN: 1420-3049.
Resumo | Links | BibTeX | Tags: <i>Bacillus subtilis</i>, <i>Xanthomonas citri</i>, Asiatic citrus canker, Chalcone
@article{nokey,
title = {Investigating the Modes of Action of the Antimicrobial Chalcones BC1 and T9A},
author = {Luana G. Morão and André S. G. Lorenzoni and Parichita Chakraborty and Gabriela M. Ayusso and Lucia B. Cavalca and Mariana B. Santos and Beatriz C. Marques and Guilherme Dilarri and Caio Zamuner and Luis O. Regasini and Henrique Ferreira and Dirk Jan Scheffers},
url = {https://www.mdpi.com/1420-3049/25/20/4596/htm https://www.mdpi.com/1420-3049/25/20/4596},
doi = {10.3390/MOLECULES25204596},
issn = {1420-3049},
year = {2020},
date = {2020-01-01},
journal = {Molecules 2020, Vol. 25, Page 4596},
volume = {25},
issue = {20},
pages = {4596},
publisher = {Multidisciplinary Digital Publishing Institute},
abstract = {Xanthomonas citri subsp. citri (X. citri) is an important phytopathogen and causes Asiatic Citrus Canker (ACC). To control ACC, copper sprays are commonly used. As copper is an environmentally damaging heavy metal, new antimicrobials are needed to combat citrus canker. Here, we explored the antimicrobial activity of chalcones, specifically the methoxychalcone BC1 and the hydroxychalcone T9A, against X. citri and the model organism Bacillus subtilis. BC1 and T9A prevented growth of X. citri and B. subtilis in concentrations varying from 20 µg/mL to 40 µg/mL. BC1 and T9A decreased incorporation of radiolabeled precursors of DNA, RNA, protein, and peptidoglycan in X. citri and B. subtilis. Both compounds mildly affected respiratory activity in X. citri, but T9A strongly decreased respiratory activity in B. subtilis. In line with that finding, intracellular ATP decreased strongly in B. subtilis upon T9A treatment, whereas BC1 increased intracellular ATP. In X. citri, both compounds resulted in a decrease in intracellular ATP. Cell division seems not to be affected in X. citri, and, although in B. subtilis the formation of FtsZ-rings is affected, a FtsZ GTPase activity assay suggests that this is an indirect effect. The chalcones studied here represent a sustainable alternative to copper for the control of ACC, and further studies are ongoing to elucidate their precise modes of action.},
keywords = {<i>Bacillus subtilis</i>, <i>Xanthomonas citri</i>, Asiatic citrus canker, Chalcone},
pubstate = {published},
tppubtype = {article}
}
Xanthomonas citri subsp. citri (X. citri) is an important phytopathogen and causes Asiatic Citrus Canker (ACC). To control ACC, copper sprays are commonly used. As copper is an environmentally damaging heavy metal, new antimicrobials are needed to combat citrus canker. Here, we explored the antimicrobial activity of chalcones, specifically the methoxychalcone BC1 and the hydroxychalcone T9A, against X. citri and the model organism Bacillus subtilis. BC1 and T9A prevented growth of X. citri and B. subtilis in concentrations varying from 20 µg/mL to 40 µg/mL. BC1 and T9A decreased incorporation of radiolabeled precursors of DNA, RNA, protein, and peptidoglycan in X. citri and B. subtilis. Both compounds mildly affected respiratory activity in X. citri, but T9A strongly decreased respiratory activity in B. subtilis. In line with that finding, intracellular ATP decreased strongly in B. subtilis upon T9A treatment, whereas BC1 increased intracellular ATP. In X. citri, both compounds resulted in a decrease in intracellular ATP. Cell division seems not to be affected in X. citri, and, although in B. subtilis the formation of FtsZ-rings is affected, a FtsZ GTPase activity assay suggests that this is an indirect effect. The chalcones studied here represent a sustainable alternative to copper for the control of ACC, and further studies are ongoing to elucidate their precise modes of action.
Morão, Luana G.; Lorenzoni, André S. G.; Chakraborty, Parichita; Ayusso, Gabriela M.; Cavalca, Lucia B.; Santos, Mariana B.; Marques, Beatriz C.; Dilarri, Guilherme; Zamuner, Caio; Regasini, Luis O.; Ferreira, Henrique; Scheffers, Dirk Jan
Investigating the Modes of Action of the Antimicrobial Chalcones BC1 and T9A Journal Article
Em: Molecules 2020, Vol. 25, Page 4596, vol. 25, iss. 20, pp. 4596, 2020, ISSN: 1420-3049.
Resumo | Links | BibTeX | Tags: <i>Bacillus subtilis</i>, <i>Xanthomonas citri</i>, Asiatic citrus canker, Chalcone
@article{nokey,
title = {Investigating the Modes of Action of the Antimicrobial Chalcones BC1 and T9A},
author = {Luana G. Morão and André S. G. Lorenzoni and Parichita Chakraborty and Gabriela M. Ayusso and Lucia B. Cavalca and Mariana B. Santos and Beatriz C. Marques and Guilherme Dilarri and Caio Zamuner and Luis O. Regasini and Henrique Ferreira and Dirk Jan Scheffers},
url = {https://www.mdpi.com/1420-3049/25/20/4596/htm https://www.mdpi.com/1420-3049/25/20/4596},
doi = {10.3390/MOLECULES25204596},
issn = {1420-3049},
year = {2020},
date = {2020-01-01},
journal = {Molecules 2020, Vol. 25, Page 4596},
volume = {25},
issue = {20},
pages = {4596},
publisher = {Multidisciplinary Digital Publishing Institute},
abstract = {Xanthomonas citri subsp. citri (X. citri) is an important phytopathogen and causes Asiatic Citrus Canker (ACC). To control ACC, copper sprays are commonly used. As copper is an environmentally damaging heavy metal, new antimicrobials are needed to combat citrus canker. Here, we explored the antimicrobial activity of chalcones, specifically the methoxychalcone BC1 and the hydroxychalcone T9A, against X. citri and the model organism Bacillus subtilis. BC1 and T9A prevented growth of X. citri and B. subtilis in concentrations varying from 20 µg/mL to 40 µg/mL. BC1 and T9A decreased incorporation of radiolabeled precursors of DNA, RNA, protein, and peptidoglycan in X. citri and B. subtilis. Both compounds mildly affected respiratory activity in X. citri, but T9A strongly decreased respiratory activity in B. subtilis. In line with that finding, intracellular ATP decreased strongly in B. subtilis upon T9A treatment, whereas BC1 increased intracellular ATP. In X. citri, both compounds resulted in a decrease in intracellular ATP. Cell division seems not to be affected in X. citri, and, although in B. subtilis the formation of FtsZ-rings is affected, a FtsZ GTPase activity assay suggests that this is an indirect effect. The chalcones studied here represent a sustainable alternative to copper for the control of ACC, and further studies are ongoing to elucidate their precise modes of action.},
keywords = {<i>Bacillus subtilis</i>, <i>Xanthomonas citri</i>, Asiatic citrus canker, Chalcone},
pubstate = {published},
tppubtype = {article}
}
Xanthomonas citri subsp. citri (X. citri) is an important phytopathogen and causes Asiatic Citrus Canker (ACC). To control ACC, copper sprays are commonly used. As copper is an environmentally damaging heavy metal, new antimicrobials are needed to combat citrus canker. Here, we explored the antimicrobial activity of chalcones, specifically the methoxychalcone BC1 and the hydroxychalcone T9A, against X. citri and the model organism Bacillus subtilis. BC1 and T9A prevented growth of X. citri and B. subtilis in concentrations varying from 20 µg/mL to 40 µg/mL. BC1 and T9A decreased incorporation of radiolabeled precursors of DNA, RNA, protein, and peptidoglycan in X. citri and B. subtilis. Both compounds mildly affected respiratory activity in X. citri, but T9A strongly decreased respiratory activity in B. subtilis. In line with that finding, intracellular ATP decreased strongly in B. subtilis upon T9A treatment, whereas BC1 increased intracellular ATP. In X. citri, both compounds resulted in a decrease in intracellular ATP. Cell division seems not to be affected in X. citri, and, although in B. subtilis the formation of FtsZ-rings is affected, a FtsZ GTPase activity assay suggests that this is an indirect effect. The chalcones studied here represent a sustainable alternative to copper for the control of ACC, and further studies are ongoing to elucidate their precise modes of action.