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2021
Vieira, Plinio S.; Bonfim, Isabela M.; Araujo, Evandro A.; Melo, Ricardo R.; Lima, Augusto R.; Fessel, Melissa R.; Paixão, Douglas A. A.; Persinoti, Gabriela F.; Rocco, Silvana A.; Lima, Tatiani B.; Pirolla, Renan A. S.; Morais, Mariana A. B.; Correa, Jessica B. L.; Zanphorlin, Leticia M.; Diogo, Jose A.; Lima, Evandro A.; Grandis, Adriana; Buckeridge, Marcos S.; Gozzo, Fabio C.; Benedetti, Celso E.; Polikarpov, Igor; Giuseppe, Priscila O.; Murakami, Mario T.
Xyloglucan processing machinery in Xanthomonas pathogens and its role in the transcriptional activation of virulence factors Journal Article
Em: Nature Communications 2021 12:1, vol. 12, iss. 1, pp. 1-15, 2021, ISSN: 2041-1723.
Resumo | Links | BibTeX | Tags: Bacterial physiology, Bacterial structural biology, Glycobiology, Pathogens
@article{Vieira2021,
title = {Xyloglucan processing machinery in Xanthomonas pathogens and its role in the transcriptional activation of virulence factors},
author = {Plinio S. Vieira and Isabela M. Bonfim and Evandro A. Araujo and Ricardo R. Melo and Augusto R. Lima and Melissa R. Fessel and Douglas A. A. Paixão and Gabriela F. Persinoti and Silvana A. Rocco and Tatiani B. Lima and Renan A. S. Pirolla and Mariana A. B. Morais and Jessica B. L. Correa and Leticia M. Zanphorlin and Jose A. Diogo and Evandro A. Lima and Adriana Grandis and Marcos S. Buckeridge and Fabio C. Gozzo and Celso E. Benedetti and Igor Polikarpov and Priscila O. Giuseppe and Mario T. Murakami},
url = {https://www.nature.com/articles/s41467-021-24277-4},
doi = {10.1038/s41467-021-24277-4},
issn = {2041-1723},
year = {2021},
date = {2021-01-01},
journal = {Nature Communications 2021 12:1},
volume = {12},
issue = {1},
pages = {1-15},
publisher = {Nature Publishing Group},
abstract = {Xyloglucans are highly substituted and recalcitrant polysaccharides found in the primary cell walls of vascular plants, acting as a barrier against pathogens. Here, we reveal that the diverse and economically relevant Xanthomonas bacteria are endowed with a xyloglucan depolymerization machinery that is linked to pathogenesis. Using the citrus canker pathogen as a model organism, we show that this system encompasses distinctive glycoside hydrolases, a modular xyloglucan acetylesterase and specific membrane transporters, demonstrating that plant-associated bacteria employ distinct molecular strategies from commensal gut bacteria to cope with xyloglucans. Notably, the sugars released by this system elicit the expression of several key virulence factors, including the type III secretion system, a membrane-embedded apparatus to deliver effector proteins into the host cells. Together, these findings shed light on the molecular mechanisms underpinning the intricate enzymatic machinery of Xanthomonas to depolymerize xyloglucans and uncover a role for this system in signaling pathways driving pathogenesis. Xyloglucans are polysaccharides found in plant cell walls. Here, the authors describe the xyloglucan depolymerization machinery of phytopathogenic Xanthomonas bacteria, and show that sugars released by this system induce the expression of key virulence factors driving pathogenesis.},
keywords = {Bacterial physiology, Bacterial structural biology, Glycobiology, Pathogens},
pubstate = {published},
tppubtype = {article}
}