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2019
Granato, Laís Moreira; Picchi, Simone Cristina; Andrade, Maxuel De Oliveira; Martins, Paula Maria Moreira; Takita, Marco Aurélio; Machado, Marcos Antonio; Souza, Alessandra Alves De
The ECNA antitoxin is important not only for human pathogens: Evidence of Its Role in the Plant Pathogen Xanthomonas citri subsp. Citri Journal Article
In: Journal of Bacteriology, vol. 201, iss. 20, pp. 25-38, 2019, ISSN: 10985530.
Abstract | Links | BibTeX | Tags: Biofilm, Quorum sensing, Stress tolerance, TA system
@article{Granato2019,
title = {The ECNA antitoxin is important not only for human pathogens: Evidence of Its Role in the Plant Pathogen Xanthomonas citri subsp. Citri},
author = {Laís Moreira Granato and Simone Cristina Picchi and Maxuel De Oliveira Andrade and Paula Maria Moreira Martins and Marco Aurélio Takita and Marcos Antonio Machado and Alessandra Alves De Souza},
url = {https://journals.asm.org/doi/10.1128/JB.00796-18},
doi = {10.1128/JB.00796-18/SUPPL_FILE/JB.00796-18-S0001.PDF},
issn = {10985530},
year = {2019},
date = {2019-01-01},
journal = {Journal of Bacteriology},
volume = {201},
issue = {20},
pages = {25-38},
publisher = {American Society for Microbiology},
abstract = {Xanthomonas citri subsp. citri causes citrus canker disease worldwide in most commercial varieties of citrus. Its transmission occurs mainly by wind-driven rain. Once X. citri reaches a leaf, it can epiphytically survive by forming a biofilm, which enhances the persistence of the bacteria under different environmental stresses and plays an important role in the early stages of host infection. Therefore, the study of genes involved in biofilm formation has been an important step toward understanding the bacterial strategy for survival in and infection of host plants. In this work, we show that the ecnAB toxin-antitoxin (TA) system, which was previously identified only in human bacterial pathogens, is conserved in many Xanthomonas spp. We further show that in X. citri, ecnA is involved in important processes, such as biofilm formation, exopolysaccharide (EPS) production, and motility. In addition, we show that ecnA plays a role in X. citri survival and virulence in host plants. Thus, this mechanism represents an important bacterial strategy for survival under stress conditions. IMPORTANCE Very little is known about TA systems in phytopathogenic bacteria. ecnAB, in particular, has only been studied in bacterial human pathogens. Here, we showed that it is present in a wide range of Xanthomonas sp. phytopathogens; moreover, this is the first work to investigate the functional role of this TA system in Xanthomonas citri biology, suggesting an important new role in adaptation and survival with implications for bacterial pathogenicity.},
keywords = {Biofilm, Quorum sensing, Stress tolerance, TA system},
pubstate = {published},
tppubtype = {article}
}
Xanthomonas citri subsp. citri causes citrus canker disease worldwide in most commercial varieties of citrus. Its transmission occurs mainly by wind-driven rain. Once X. citri reaches a leaf, it can epiphytically survive by forming a biofilm, which enhances the persistence of the bacteria under different environmental stresses and plays an important role in the early stages of host infection. Therefore, the study of genes involved in biofilm formation has been an important step toward understanding the bacterial strategy for survival in and infection of host plants. In this work, we show that the ecnAB toxin-antitoxin (TA) system, which was previously identified only in human bacterial pathogens, is conserved in many Xanthomonas spp. We further show that in X. citri, ecnA is involved in important processes, such as biofilm formation, exopolysaccharide (EPS) production, and motility. In addition, we show that ecnA plays a role in X. citri survival and virulence in host plants. Thus, this mechanism represents an important bacterial strategy for survival under stress conditions. IMPORTANCE Very little is known about TA systems in phytopathogenic bacteria. ecnAB, in particular, has only been studied in bacterial human pathogens. Here, we showed that it is present in a wide range of Xanthomonas sp. phytopathogens; moreover, this is the first work to investigate the functional role of this TA system in Xanthomonas citri biology, suggesting an important new role in adaptation and survival with implications for bacterial pathogenicity.