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2020
Martins, Paula Maria Moreira; Gong, Ting; Souza, Alessandra A.; Wood, Thomas K.
Copper Kills Escherichia coli Persister Cells Journal Article
In: Antibiotics 2020, Vol. 9, Page 506, vol. 9, iss. 8, pp. 506, 2020, ISSN: 2079-6382.
Abstract | Links | BibTeX | Tags: Copper, persister, VBNC
@article{Martins2020,
title = {Copper Kills Escherichia coli Persister Cells},
author = {Paula Maria Moreira Martins and Ting Gong and Alessandra A. Souza and Thomas K. Wood},
url = {https://www.mdpi.com/2079-6382/9/8/506/htm https://www.mdpi.com/2079-6382/9/8/506},
doi = {10.3390/ANTIBIOTICS9080506},
issn = {2079-6382},
year = {2020},
date = {2020-01-01},
journal = {Antibiotics 2020, Vol. 9, Page 506},
volume = {9},
issue = {8},
pages = {506},
publisher = {Multidisciplinary Digital Publishing Institute},
abstract = {Due to their reduced metabolism, persister cells can survive most antimicrobial treatments, which usually rely on corrupting active biochemical pathways. Therefore, molecules that kill bacterial persisters should function in a metabolism-independent manner. Some anti-persister compounds have been found previously, such as the DNA-crosslinkers mitomycin C and cisplatin, but more effective and lower cost alternatives are needed. Copper alloys have been used since ancient times due to their antimicrobial properties, and they are still used in agriculture to control plant bacterial diseases. By stopping transcription with rifampicin and by treating with ampicillin to remove non-persister cells, we created a population that consists solely of Escherichia coli persister cells. Using this population of persister cells, we demonstrate that cupric compounds kill E. coli persister cells. Hence, copper ions may be used in controlling the spread of important bacterial strains that withstand treatment with conventional antimicrobials by forming persister cells.},
keywords = {Copper, persister, VBNC},
pubstate = {published},
tppubtype = {article}
}
Due to their reduced metabolism, persister cells can survive most antimicrobial treatments, which usually rely on corrupting active biochemical pathways. Therefore, molecules that kill bacterial persisters should function in a metabolism-independent manner. Some anti-persister compounds have been found previously, such as the DNA-crosslinkers mitomycin C and cisplatin, but more effective and lower cost alternatives are needed. Copper alloys have been used since ancient times due to their antimicrobial properties, and they are still used in agriculture to control plant bacterial diseases. By stopping transcription with rifampicin and by treating with ampicillin to remove non-persister cells, we created a population that consists solely of Escherichia coli persister cells. Using this population of persister cells, we demonstrate that cupric compounds kill E. coli persister cells. Hence, copper ions may be used in controlling the spread of important bacterial strains that withstand treatment with conventional antimicrobials by forming persister cells.
2018
Martins, Paula M. M.; Merfa, Marcus V.; Takita, Marco A.; Souza, Alessandra A. De
Persistence in phytopathogenic bacteria: Do we know enough? Journal Article
In: Frontiers in Microbiology, vol. 9, iss. MAY, pp. 1099, 2018, ISSN: 1664302X.
Abstract | Links | BibTeX | Tags: Crop diseases, Oxidative stress, Persisters, Phytopathogen, Toxin-antitoxin systems, VBNC
@article{Martins2018,
title = {Persistence in phytopathogenic bacteria: Do we know enough?},
author = {Paula M. M. Martins and Marcus V. Merfa and Marco A. Takita and Alessandra A. De Souza},
doi = {10.3389/FMICB.2018.01099/BIBTEX},
issn = {1664302X},
year = {2018},
date = {2018-01-01},
journal = {Frontiers in Microbiology},
volume = {9},
issue = {MAY},
pages = {1099},
publisher = {Frontiers Media S.A.},
abstract = {Phytopathogenic bacteria affect a wide range of crops worldwide and have a negative impact in agriculture due to their associated economic losses and environmental impacts. Together with other biotic and abiotic stress factors, they pose a threat to global food production. Therefore, understanding bacterial survival strategies is an essential step toward the development of new strategies to control plant diseases. One mechanism used by bacteria to survive under stress conditions is the formation of persister cells. Persisters are a small fraction of phenotypic variants within an isogenic population that exhibits multidrug tolerance without undergoing genetic changes. They are dormant cells that survive treatment with antimicrobials by inactivating the metabolic functions that are disrupted by these compounds. They are thus responsible for the recalcitrance of many human diseases, and in the same way, they are thought to contribute to the survival of bacterial phytopathogens under a range of stresses they face in the environment. It is believed that persister cells of bacterial phytopathogens may lead to the reoccurrence of disease by recovering growth and recolonizing the host plant after the end of stress. However, compared to human pathogens, little is known about persister cells in phytopathogens, especially about their genetic regulation. In this review, we describe the overall knowledge on persister cells and their regulation in bacterial phytopathogens, focusing on their ability to survive stress conditions, to recover from dormancy and to maintain virulence.},
keywords = {Crop diseases, Oxidative stress, Persisters, Phytopathogen, Toxin-antitoxin systems, VBNC},
pubstate = {published},
tppubtype = {article}
}
Phytopathogenic bacteria affect a wide range of crops worldwide and have a negative impact in agriculture due to their associated economic losses and environmental impacts. Together with other biotic and abiotic stress factors, they pose a threat to global food production. Therefore, understanding bacterial survival strategies is an essential step toward the development of new strategies to control plant diseases. One mechanism used by bacteria to survive under stress conditions is the formation of persister cells. Persisters are a small fraction of phenotypic variants within an isogenic population that exhibits multidrug tolerance without undergoing genetic changes. They are dormant cells that survive treatment with antimicrobials by inactivating the metabolic functions that are disrupted by these compounds. They are thus responsible for the recalcitrance of many human diseases, and in the same way, they are thought to contribute to the survival of bacterial phytopathogens under a range of stresses they face in the environment. It is believed that persister cells of bacterial phytopathogens may lead to the reoccurrence of disease by recovering growth and recolonizing the host plant after the end of stress. However, compared to human pathogens, little is known about persister cells in phytopathogens, especially about their genetic regulation. In this review, we describe the overall knowledge on persister cells and their regulation in bacterial phytopathogens, focusing on their ability to survive stress conditions, to recover from dormancy and to maintain virulence.